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What is Frontline Plus?

Frontline Plus is a monthly topical flea and tick preventative for pets. It kills 100% of adult fleas on your pet within 12 hours and 100% of all ticks and chewing lice within 48 hours.

Frontline Plus for dogs comes in four different pipette sizes for different weight ranges and you should use the whole of the pipette on your dog. For dogs you should apply it on the back of their necks and on their back in a line, this will ensure your dog is fully protected.

Frontline for cats is just as effective and comes in a smaller variety as cat sizes don’t vary drastically from one another. Frontline is applied to the spot between your cat’s shoulder blades on the skin, and then they will be protected for the next month.


Who is Frontline Plus for?

For dogs over 8 weeks weighing at least 4.4 lbs (2 kg) and for cats over 8 weeks weighing at least 1.5 lbs (0.7 kg).

Dosage Schedule

Frontline Plus for dogs

Body Weight Ranges Monthly Dose Fipronil (S)-methoprene
4.4 to 9.9 lbs (2-10 kg) 0.67 mL (0.023 fl oz) 9.8% 8.8%
23 to 44 lbs (10-20 kg) 1.34 mL (0.045 fl oz) 9.8% 8.8%
45 to 88 lbs (20-40 kg) 2.68 mL (0.091 fl oz) 9.8% 8.8%
89 to 132 lbs (40-60 kg) 4.02 mL (0.136 fl oz) 9.8% 8.8%

*Do not reapply for 30 days.

Frontline Plus for cats

Body Weight Range Monthly Dose Fipronil (S)-methoprene
Over 1.5 lbs (0.7 kg) 0.50 mL (0.016907 fl oz) 9.8% 11.8%

*Do not reapply for 30 days.

NexGard Spectra is a new product that offers complete protection against fleas, ticks, heartworm and intestinal worms for a full month.

How does Frontline Plus work?

After an application, fipronil and (S)-methoprene spread through the oil-rich surfaces of the skin and concentrate in the oil glands to form a reservoir. A small amount is then continuously released onto the skin surface and hair. This provides long-lasting protection and makes it resistant to the effects of water and shampoo. It is not absorbed into the bloodstream of your pet.

Frontline Plus combines fipronil to kill adult fleas on your pet and (S)-methoprene to kill flea eggs and larvae and stop pupal development.

What are the side effects?

Pets may experience some temporary irritation after application.

What special precautions are there?

Not for human use. Keep this and all drugs out of the reach of children. Keep the product in the original packaging until use, in order to prevent children from getting direct access to the product.

Who manufactured Frontline Plus?

Frontline Plus is made by Merial (Boehringer Ingelheim Animal Health).

Brand Comparison

Frontline Plus For Dogs & Cats

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    4.9 out of 5 stars
    • 5 star 94%
    • 4 star 2%
    • 3 star 2%
    • 2 star 2%
    • 1 star 0%
    I use this product from many years.
    효과 좋습니다.
    부담없이 바르고, 효과는 좋아요. 3월~10월까지 한달에 한번씩 발라주고 있습니다.
    S. Park
    very good!!
    very good!!very good!!
    D. Bar-Yakov
    Does a Good Job
    Protects our cat well.
    P. Hebb
    Vet-recommended switch
    Two of my cats were having flea-related skin issues. The vet recommended that I switch from the high quality brand I was using to another high quality brand to see if that would produce better results. He recommended Frontline. From the first application, the issues were resolved. This experience showed me that I needed to match my desire for quality with the compatibility of the animal.